Successful Treatment with Tacrolimus in a Case of the Glucocorticoid-Dependent Recurrent Cutaneous Eosinophilic Vasculitis

252 Ann Dermatol Received May 15, 2012, Revised August 1, 2012, Accepted for publication August 16, 2012 Corresponding author: Masafumi Sugiyama, Department of Hematology and Rheumatology, Kinki University School of Medicine, 377-2 OhnoHigashi Osaka-Sayama, Osaka 589-8511, Japan. Tel: 81-72-366-0221, Fax: 81-72-368-3732, E-mail: [email protected] This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http:// creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. lentiginous nevus, is considered within the spectrum of congenital melanocytic nevi, due to its usual occurrence during late infancy or early childhood. Dark brown pigmented macules and papules lying on a tan lentiginous patch is the characteristic finding. Histologically, the background area resembles lentigo simplex, whereas the darker spots usually show the features of a lentiginous nevus with lentigo-like areas progressing to junctional and even small compound nevi. In contrast, agminated nevi usually occur during puberty and lack background pigmentation. In our case, background pigmentation was not clinically visible, and the small amount of normal tissue surrounding the excised nevus did not reveal a lentiginous feature. Since melanoma arising from acquired agminated melanocytic nevi has been described and the patient is relatively young, long-term follow-up for any malignant change as well as development of background pigmentation is warranted.